Natalia Gussoni (born 24 August 1981) is a retired Argentine tennis player.

Gussoni has career-high WTA rankings of 134 in singles, achieved on 3 May 2004, and 220 in doubles, reached on 5 July 2004.

She won seven singles and three doubles titles on the ITF Circuit.

Playing for Argentina in Fed Cup competitions, Gussoni has a win–loss record of 3–3.