Mariana Mesa Pineda (born 1 April 1980) is a Colombian former professional tennis player.

She featured in a total of 12 ties for Colombia during her career, mostly as doubles player, winning seven matches overall.

On the WTA Tour, she made most of her main-draw appearances at her home event, the Copa Colsanitas, playing in every edition of the tournament from 1998 to 2000.

Mesa reached a best singles ranking on tour of 251 in the world and won five ITF Women's Circuit tournaments.

At the 2000 Summer Olympics in Sydney, Mesa represented Colombia in the doubles competition, with Fabiola Zuluaga as her partner.