Although her literary contributions were relatively minor, she is noted for being at the center of a love triangle involving her first husband, Ștefan Octavian Iosif, and her second, Dimitrie Anghel.

Born in Buciumeni, Tecuci County, her parents were Avram Negru, a teacher, and his wife Elena (née Dumitrescu).

Fond of reading in the University Foundation Library, she met its caretaker, the published poet Ștefan Octavian Iosif, in 1903.

[2] The couple married in July 1904; the three-day wedding took place at Tecucel on the outskirts of Tecuci, where her father had built her a house and granted her ten hectares of vineyards.

[2] Dimitrie Anghel, Iosif's closest friend and a collaborator on poems, visited the family home almost daily and fell in love with Natalia.

In December, after suing but before the divorce was granted, she traveled to Paris for health reasons and later invited Iosif to spend a month together, presumably seeking a reconciliation.

[2] Negru and Anghel married in November 1911; the union created hostility around them, especially in the literary circles that valued Iosif's poetry and his delicate temperament.

[2] The couple had frequent scenes involving screams, explosive emotions and sudden reconciliations; on at least one occasion, Anghel broke down a door and embraced his wife's feet in tears.

[4][5] In September 1916, shortly after Romania entered World War I, her daughter was killed by shrapnel from a bomb dropped by a Zeppelin.

[4] She published translations of Hans Christian Andersen, Gustave Aimard, André Theuriet, Nicholas Wiseman (Fabiola) and Prosper Mérimée (Colomba).

A slightly more appreciative Victor Durnea finds "a certain lyrical, ingenuous sensibility" that can be "glimpsed.... in the recovery of certain childhood and adolescent memories".