She was born into a musical family; her grandmother once sang in a choir, while father was a professional musician.

She started to sing in a public choir "Pysanka" and later became a solo singer for the vocal-instrumental ensemble "Halytska perlyna" (Halych Perl) headed by Lesya Salistra.

During her studies in universities Karpa was a solo singer for a medical jazz band "Medicus".

[1] Along her singing career, Karpa also is an anchor lady for few TV-programs such as "Ekstremalnyi weekend" (NTA) and "Vidkryi sebe" (Television and Radio company "Lyuks").

Natalka Karpa also founded a line of cosmetics and released her own perfumes.