[2] After high school, Natalya spent a year on self-education and additional documents filed immediately and Boris Shchukin Theatre Institute, and Mikhail Shchepkin Higher Theatre School.

After graduation from the school, Natalia worked in the theaters Moscow Chamber Troupe, The Ark, Sphere.

In the Moscow theater Sphere, Horohorina served eleven years.

Her acting debut in cinema was in the drama of Georgiy Kalatozishvili Cafe Isotope in 1976.

Notable films with her participation include Mustached Nanny (1977), White Dew (1983), Unknown Soldier (1984), Entrance to the Labyrinth (1989), Zone of Lyube (1994), Demobbed (2000), The Spanish Voyage of Stepanich (2006) and television series Voronin's Family (2009-2014).