After going to Wheaton College, Saint married Marjorie Farris (commonly called Marj) in 1948 and eventually moved to Shell, Ecuador.

In September 1955, Saint was joined by his teammates, Jim Elliot, Ed McCully, Pete Fleming, and Roger Youderian.

[2] In 1966, Marjorie (Marj) Farris Saint married Abe Van Der Puy, president of HCJB World Radio.

Saint's older son, Steve, spent time as a child visiting his missionary family members and friends and getting to know the Huaorani.

Steve Saint also helped write Jungle Pilot, based on his father's diary about his time in Ecuador and work with the Huaorani Indians.

Steven Curtis Chapman wrote the song "No Greater Love" from his album Declaration as a tribute to Saint and his fellow missionaries.