She attended the Philadelphia School of the Bible (now Cairn University) and then worked at the Keswick Colony of Mercy in New Jersey, a rehabilitation facility for people with alcohol addiction.

Her work there began to become well-known after the publication of the life of Tariri, a Shapra chief who left head-hunting after being introduced to Christianity.

In 1957, she embarked on a tour of the United States together with Dayuma, appearing with Billy Graham at Madison Square Garden and on Ralph Edwards' television show This Is Your Life.

Where the five American men had failed to gain entrance into the Waorani society, these two unarmed women (as well as Elliot's little daughter) were not perceived as a threat.

[8] Saint appears in Joe Kane's book, Savages, in which she is criticized for the negative effects her proselytizing allegedly had on the lifestyle of those Waorani who chose to live in her village.