Nathan Frank (February 23, 1852 – April 5, 1931) was a U.S. Representative from Missouri.

Born in Peoria, Illinois, Frank attended the public schools of Peoria and St. Louis and Washington University in St. Louis.

He unsuccessfully contested the election of John M. Glover to the Fiftieth Congress in 1886.

He served as vice president of the Louisiana Purchase Exposition at St. Louis in 1904.

He was an unsuccessful candidate for nomination for United States Senator in 1910, 1916, and 1928.