Known for his immense 7-foot-5-inch (226 cm) wingspan, he played college basketball for the San Diego State Aztecs.

In August 2017, he averaged 13.8 points and 7.4 rebounds per game for Team Africa in the Adidas Global Nations event.

[3] On 28 December 2019, Mensah requested to be substituted during the second half of a game against Cal Poly, due to shortness of breath.

[11] On 14 December, he signed a two-way contract with the Hornets[12] and the next day, he made his NBA debut in a 112–107 loss to the New Orleans Pelicans.

[17] On 11 December 2024, Mensah signed with Olympiacos of the Greek Basketball League, replacing the injured Moses Wright.