Nathaniel Freeman (March 28, 1741 – September 20, 1827) was an American physician and jurist.

He was a brigadier general during the American Revolutionary War and a member of the Massachusetts House of Representatives in 1775.

He settled at Sandwich (also Barnstable County) in 1763 where he established a medical practice.

In September of 1774 he was chosen the leader of a mass protest against the British "Intolerable Acts," which won the agreement of county officials to ignore the requirements of Parliament's new legislation.

The following year was elected a member of the Massachusetts House of Representatives and was appointed colonel of a militia regiment.