The National Center for Toxicological Research (NCTR) is a branch of the U.S. Food & Drug Administration (FDA) located in Jefferson, Arkansas.

Established in 1971, the Center conducts scientific research to provide reliable data for Food & Drug Administration decision-making and develops innovative tools and approaches that support its public health mission.

The National Center for Toxicological Research is geographically adjacent to the Pine Bluff Arsenal, and was once an integrated part of the installation.

[1] The U.S. Army Chemical Corps used the facility for biological warfare research and chemical weapons development until 1969, when President Richard Nixon signed an executive order banning such research from military facilities, and the Army subsequently transferred operation of the site to the FDA.

It is the only FDA center located outside the Washington, D.C. metropolitan area,[3] and its campus takes up approximately 1 million square feet.