It starts from NH 16 junction at Kattipudi and passes through Kakinada, Amalapuram, Digamarru (Palakollu), Narasapuram, Bantumilli, Machilipatnam, Repalle, Cherukupalle, Bapatla, Chirala before it junctions NH 16 again at Ongole.

National Highway 216 starts from NH16 at Kathipudi village and it passes through towns and cities like Gollaprolu, Pithapuram, Kakinada, Yanam, Mummidivaram, Amalapuram, Razole, Digamarru (Palakollu), Narsapuram, Bantumilli, Pedana, Machilipatnam, Repalle, Cherukupalle, Bapatla, Chirala and connects with NH 16 at Ongole.

The National Highway-216 stretches from Kathipudi in East Godavari to Ongole in Prakasam district, covering a distance of 456 kilometers along the seacoast and passing through West Godavari, Krishna, and Guntur districts.

It begins at Kathipudi, intersects NH-16 between Visakhapatnam and Rajamahendravaram, and reconnects to NH-16 at Ongole after traversing the five coastal districts.

From Kakinada suburbs a bypass road is under progress from Atchampeta in Kakinada rural to Uppalankamondi in Karapa mandal for a distance of about 20 kilometres touching Madhavapatnam, Kovvada, Turangi villages in Kakinada rural, Chollangi village and from there to culvert at Uppalam Kamondi with ROB near Sarpavaram junction railway station with an estimated cost of Rs 150 crore.