The RN-6 National Highway is a national highway in southwestern Djibouti.

The highway begins at 11°06′32″N 42°20′47″E / 11.10889°N 42.34639°E / 11.10889; 42.34639 (National Highway 6, eastern end), at a junction with National Highway 1 near Dikhil.

It passes through the town of As Eyla and ends at the village of Kouta Bouyya (11°00′55″N 41°58′37″E / 11.01528°N 41.97694°E / 11.01528; 41.97694 (National Highway 6, western end)).

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