The National Indian Gaming Commission (NIGC; /nɪɡˈsiː/) is a United States federal regulatory agency within the Department of the Interior.

IGRA placed the commission within the Department of the Interior (DOI), but also provided it with independent federal regulatory authority.

Because the National Indian Gaming Commission is subject to the Government Performance and Results Act of 1993, they submitted in 2022 a strategic plan to Congress, which covers the fiscal years 2022 to 2026.

The commission comprises a chair and two commissioners, each of whom serves on a full-time basis for a three-year term.

In addition to auditing and investigative activities, the field staff provides technical assistance and training to promote a better understanding of gaming controls within the regulated industry, and to enhance cooperation and compliance to ensure the integrity of gaming operations.