National Route 158 is a highway in Argentina, which is located in the center-east of the province of Córdoba.

From the junction with National Route 19 in San Francisco to the junction with National Route 36 in Río Cuarto, it travels 285 kilometres (177 mi).

This road is part of the Mercosur-Chile Corridor, defined by IIRSA as one of the three integration axes in Argentina.

By means of an agreement made on 19 October 1976, this route passed into national jurisdiction.

With the incorporation of the new section, new roads were opened for 118.5 kilometres (73.6 mi).