National Secondary Route 221, or just Route 221 (Spanish: Ruta Nacional Secundaria 221, or Ruta 221) is a National Road Route of Costa Rica, located in the San José, Cartago provinces.

[1] In San José province the route covers Curridabat canton (Curridabat, Granadilla, Sánchez districts).

In Cartago province the route covers La Unión canton (Tres Ríos, Concepción, Dulce Nombre districts).

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