National Secondary Route 251, or just Route 251 (Spanish: Ruta Nacional Secundaria 251, or Ruta 251) is a National Road Route of Costa Rica, located in the San José, Cartago provinces.

[1] In San José province the route covers Curridabat canton (Curridabat, Sánchez districts).

In Cartago province the route covers La Unión canton (Tres Ríos, San Juan, San Rafael districts).

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