The National Space Defense Center (NSDC) is a subordinate center of United States Space Command's Joint Task Force–Space Defense.

The NSDC is located at Schriever Space Force Base, outside of Colorado Springs.

[3] Initially established as the Joint Interagency Combined Space Operations Center (JICSpOC) on 1 October 2015, it was intended to improve processes and procedures, ensuring data fusion among DoD, intelligence community, interagency, allied and commercial space entities.

[1] On 1 April 2017, the JICSpOC was renamed the National Space Defense Center, to better clarify its role and eliminate confusion with the Joint Space Operations Center (JSpOC).

[4] On 9 July 2019, the NSDC dedicated its operations floor and a warfighter library to Senior Master Sergeant Harold Robert Mosley II.