After the Chinese Civil War, president Mei Yiqi and other academics fled with the retreating Nationalist government to Taiwan, where they founded National Tsing Hua University in 1956.

The research cluster and its neighboring Hsinchu Science Park together play a key role in the global semiconductor industry.

In 1955, the President of Tsinghua University in Beijing, Mei Yi-chi left and re-established the National Tsing Hua Institute of Nuclear Technology in Hsinchu, and later based on the foundation of the original institute, National Tsing Hua University was founded in Taiwan.

Using this fund, Tsinghua College (清華學堂, Qīnghuá Xuétáng) was established in Beijing, China, on 22 April 1911 on the site of a former royal garden belonging to a prince.

NTHU has been consistently ranked as one of the premier universities in Taiwan and is widely recognized as the best incubator for future leaders in industries as well as academics.

Such stellar records are particularly exemplified by the outstanding achievements of alumni, including two Nobel laureates in physics (Dr. Chen-Ning Yang and Tsung-Dao Lee), one Nobel laureate in chemistry (Dr. Yuan-Tseh Lee) and one Wolf Prize winner in mathematics (Dr. Shiing-Shen Chern).

Since its establishment in 1969, the tournament, also known as the Mei-Chu Games, has become a tradition, and is considered one of the most important activities between these two prestigious universities in Taiwan.

The arrangement of the formal event, however, was not institutionalized until 1968, when Chian Feng, an executive officer of NTHU student activity center, received the permission from the university authority to plan sport events for NTHU and NCTU students modeling after the Oxford and Cambridge Boat Race.

As the head-side of the coin went up, the tournament was thereby named Meichu to commemorate the two founding presidents of NTHU and NCTU, Mei Yi-chi and Ling Chu-Ming.

Club activities range from community services, music and sports, cinema and theater, dancing and martial arts, religion and philosophy as well as scientific and academic interests.

A University Clinic,[26] affiliated with Hsinchu Mackay Memorial Hospital, is located on campus where first aid and general medical services are provided.

The clinic and the center not only provide services when needed and organize and present educational programs for all students.