It attempts to keep the comments written in source code just as readable as the generated documentation.

Theoretically, Natural Docs can generate documentation from any language that can support comments, or from plain text files.

When executed, it can automatically document functions, variables, classes, and inheritance from ActionScript, C#, and Perl regardless of existing documentation in the source code.

Unlike Javadoc, it is not considered an industry standard for documenting in any language, although it can incorporate Javadoc documentation for languages with "full support.

"[2] It is used by some hobbyists and companies, such as CNET Networks, Inc. and Iron Realms Entertainment.