Naughton has sung the national anthem at various events in New Jersey and attended Seton Hall University.

In August 2002, the group was set to release its newest LP, A Girl Can Mack, when Naughton announced that she was no longer a member of the trio.

In May 2017, Naughton reunited with Bailon on the daytime talk show The Real,[8] while promoting the season premiere of Power.

[10] In 2010, an extended play was released, titled Fame Presents Naturi Naughton as Denise: Didn't I Tell You?.

In August 2010, Naughton was announced to appear in an episode of the AMC drama television series Mad Men.

[20] The episode, "Hands and Knees", which aired on September 26, 2010, saw Naughton portray the role of Toni Charles, a Playboy Bunny mistress to the character Lane Pryce.

[24] In October 2011, Naughton appeared as a 1970s jazz club singer named Shadynasty in an episode of the sitcom It's Always Sunny in Philadelphia.

[25] In December 2011, it was announced Naughton had been cast in the Lifetime drama television series The Client List opposite Jennifer Love Hewitt.

[29] In September 2012, Naughton starred in the BET original film Let The Church Say Amen, which is an adaptation of author ReShonda Tate Billingsley's 2005 best-selling novel of the same name.

Naughton reprised her role as Tasha in the spin-off series Power Book II: Ghost, which began airing in September 2020.

On March 8, 2021, it was announced that Naughton had joined the cast of American Broadcasting Company's music series Queens, alongside Brandy and Eve.

[38] On October 1, 2021, the first promo single from Queens (“Nasty Girl"), featuring Naughton alongside the cast: Brandy, Eve and Velazquez, was released.

Caroline Framke for Variety praised the quartet’s musical offering, calling their raps “sharp and distinct […] making clear their talent as both individuals and a swaggering collective”.

[45] In April 2022, Naughton married talent manager and entrepreneur Xavier "Two" Lewis in a lavish wedding ceremony in Atlanta.