Largely industrial, and home to over 150 warehouses containing 8,800,000 square feet (820,000 m2) of storage space[1] and other buildings, it is the headquarters of the Naval Supply Systems Command.

[2] By the early 1940s, with the United States engaged in World War II, it became clear that the Navy needed inland supply depots.

The next major change occurred July 1972, when the Naval Supply Depot merged with the Navy Ships Parts Control Center.

The 1990s witnessed some reorganization, as SPCC merged with the Aviation Support Office in Philadelphia to form the Naval Inventory Control Point (NAVICP).

In July 1996, the Naval Supply Systems Command (NAVSUP) Headquarters moved into Mechanicsburg from its leased facilities in Crystal City, Virginia.