Rojo debuted in Los Angeles, California during a Youth Congress led by Luis Enrique Espinosa, brother of Emmanuel.

[1] In 2001, they released their eponymous debut album and started touring through Latin America, United States, Spain, and Japan.

During this time, lead singer Annette Moreno, decided to start a solo career and left the band.

[2][3] After almost two years of touring, the band released their second album, titled 24/7 in 2003, which featured songwriting collaborations by Juan Salinas and Jesús Adrián Romero.

In May 2007, the band released their fourth studio album titled Con el Corazón en la Mano.