The first season of the show initially starred Vijayalakshmi but later she was replaced by Vidya Pradeep with Dhilip Rayan and Ambika.

She marries Thirumurugan "Thiru", son of the Kalivaradan, who killed Anandhi's real father and took his property.

Thiru's childhood friend, Ananya is Anandhi's half-cousin, whose mother is the half-sister of Leelavathi.

After chasing his two siblings, Gopi plans to take Kanmani's councillor posting but it fails.

Then, he plans to stop the marriage but Aakash kidnaps Ezhilan and blackmiles Divya to marry him.

Ezhilan later escapes and Aakash kidnaps Divya's younger sister Savitha to blackmail her.

Ezhilan and his friend Ashok come in the form of two priests and enter Rajalakshmi's house where the wedding is happening.

Due to COVID-19 outbreak in India, the production was halted in mid March 2020, Nayagi was put on hiatus on Wednesday 3 April 2020 when the remaining episodes aired.

[2] Post COVID-19 break, the production resumed in July 2020 and new episodes started to telecast from 27 June 2020.

[3] During which, the story had a change in leads and story with a new season along with many new additions starring Krishna and Nakshathra Nagesh while former lead characters Thiru, Anandhi and their family's track being ended abruptly, while Sargunam and Kanmani's family track continued.

[6] Actress Vidya Pradeep was selected to portray the role of Anandhi after the exit of Vijayalakshmi.

[7] Sun TV Anchor Dhilip Rayan was cast in the lead male role of Thirumurugan.

Malayalam Actress Meera Krishnan was selected to play Vasanthi, after having appeared in director Thiruselvam Tamil serial Pokkisham (2012–2013).

[8] On 10 February 2018, the first promo of Ambika's 'Naayagi Teaser: Sarkunam' was released by Vikatan TV on YouTube.

Until before COVID-19 break in March 2020, the series used to be one of the top five Tamil television programs consistently.

[12] However when the series resumed its airing post Covid-19 break with the change in its story, main lead and time slot from 8:00 pm (IST) to 9:00 pm (IST), in July 2020, the ratings of the series had a drastic drop and it was off aired in October 2020.