Nazareth Academy opened in 1897 and received a charter from the State of Michigan which provided for the future extension of the school to the collegiate level.

Under the Presidency of Sister Mary Bader, S.S.J., (1962-1974),[1] the decision was made in 1971 to admit men to the college, thus changing the campus culture forever.

Nazareth College was also noted for its night and weekend classes designed to meet the needs working adult students.

In 1987 it offered bachelor's degree programs in: accounting, America studies, biology, business administration, computer information management, elementary education, English, fine arts, fine arts management, human services, learning disabilities, liberal studies, medical technology, natural science, nursing, pharmaceutical and medical services representative, pre-medical pre-dental and pre-veterinary, secondary education, social psychology, and social work.

Connors, Dooley and Albers Halls have been leased to Kalamazoo County Health and Community Services Department.

The college seal, that was inlaid in the main floor of the administration building, was saved and is now on display on the grounds of former campus.