[7][8] Mestaoui was a co-founder of LAb(au), an artists group in Brussels, Belgium which explored the impact of advanced technologies on art, from 1997 to 2000.

[9] Beginning in 2000, Naziha Mestaoui worked with Yacine Aït Kaci in the duo Electronic Shadow, pioneering and patenting techniques of videomapping in digital art.

[13][14] For the 4th Biennale of Moscow in 2011, they worked with the musician 2square (Stephan Haeri of Télépopmusik) to create the interactive piece Chaos Theory.

[15] Their permanent light installation Résonances was created as an interactive skin for the outside of the FRAC Centre in Orléans, France, which opened on September 14, 2013.

[16] As joint winners in the competition, they worked with architects Jakob + MacFarlane who created the prefabricated tubular structure known as The Turbulences.

By placing diodes on the structural lines of the anodised aluminium casing, Mestaoui and Kaci created a real-time "interactive ‘veil of light'" that is responsive to local climate and environmental data.

[20][21] The 2014 interactive installation Corps en résonance (Echoing bodies) generated sound and light displays in crystal bowls filled with water, in response to the movements of visitors.

[2] Naziha Mestaoui's light installation One heart, One tree was inspired by her experiences traveling among aboriginal peoples in the Amazon, India, and Oman.

[2] The images created as part of One heart, One tree were projected onto monuments in Paris during the United Nations Climate Conference (COP21) in December 2015.