Neabsco Creek is a 13.9-mile-long (22.4 km)[1] tributary of the lower tidal segment of the Potomac River in eastern Prince William County, Virginia.

The creek has served as a vital waterway for trade and commerce in northern Virginia since the eighteenth century.

The EPA Office of Water recently identified the Neabsco Creek watershed as an "area of significant habitat degradation due to a loss of natural land cover and storm water management facilities designed without consideration for environmental conditions."

Congressman Tom Davis secured more than $4 million in funds to clean up the Dale Service Corporation's sewage treatment plant on Neabsco Creek.

Featherstone National Wildlife Refuge, 325 acres (1.32 km2) of tidal marsh and riparian wetlands and woodlands, is located about 22 miles (35 km) south of Washington, D.C. at the confluence of Neabsco Creek and the Potomac River and provides a habitat for neotropical migrants, waterfowl, ospreys, and historically bald eagles.