It was within the site of the current London Underground Neasden Depot.

The station was commissioned in 1904 with three British Westinghouse turbo-generators rated at 3,500 kW each.

The station was further upgraded in 1912 when the original turbines were replaced.

Coal for the power station was brought in by trains, initially by the Metropolitan Railway using its fleet of steam locomotives, from June 1935 by the London & North Eastern Railway, and from 1948 British Rail.

By 1957 the plant comprised eleven boilers, five were chain grate stokers and six were heavy fuel oil.