Its southern terminus is at the Kansas border south of Trenton.

Nebraska Highway 25 begins at the Kansas border and serves as a continuation of K-25.

It goes north into farmland and near the Swanson Reservoir before it turns northeast to go into Trenton.

It continues north for 8 miles (13 km), where it meets U.S. Highway 6.

The highway functions as a spur route into Palisade from N-25.