N-35 is maintained by the Nebraska Department of Transportation (NDOT) and serves as a connector between Norfolk and Sioux City, Iowa.

For its entire length (except when it passes through the cities of Wayne and Wakefield) N-35 runs through rural agricultural land.

From its western terminus N-35 initially heads northerly as a four–lane divided highway along an old alignment of US 275 (and subsequently the former U.S. Route 273 Business loop [US 275 Bus]).

[1][3] About 1.8 miles (2.9 km) northeast, after entering Stanton County and passing along the northwestern edge of the unincorporated community of Woodland Park, N-35 connects with the west end of NE Industrial Drive and then narrows to a two-lane road.

)[1][3] After continuing northeast for approximately 0.8 miles (1.3 km) in Wayne County, N-35 curves to head east along 847th Road and then immediately connects with the south end of Nebraska Spur 90A (S-90A) at a T intersection.

Three miles (4.8 km) farther north, N-35 connects with the west end of Nebraska Highway 98 (N-98) at a T intersection on 856th Road.

After 1 mile (1.6 km), and after passing along the southern edge of the Greenwood Cemetery, N-35 reaches Nebraska Highway 15 (N-15/Main Street) at the center of Wayne.

From its junction with N-16, N-35 heads north along 584th Avenue for about 1.7 miles (2.7 km) before entering the city of Wakefield along Oak Street.

)[3] After continuing east for about one and a half miles (2.4 km), but now along 260th Street and in Dakota County, N-35 begins a somewhat winding northeasterly course.

After roughly one-half mile (0.80 km) N-35 reaches the southern end of Nebraska Highway 110 (N-110) at G Avenue.