U.S. Highway 77 (US 77) in the state of Nebraska runs south–north across the eastern portion of the state, emerging from Kansas in Gage County south of Wymore, and ending in Dakota County north of South Sioux City, before making a brief entrance into Iowa.

In Nebraska, US 77 is a major north–south artery connecting the capital city of Lincoln with outlying areas to the north and south.

US 275 and N-91 separate from US 77 just south of Winslow, Nebraska and US 77 continues north as a two-lane highway until it meets U.S. Route 75 at Winnebago.

The two highways run together to the junction of I-129 and US 20 at Dakota City, where US 75 breaks off and US 77 continues northward as a divided highway through South Sioux City before exiting the state via the Siouxland Veterans Memorial Bridge.

The national end of US 77 lies four-tenths mile (640 m) on the other side of the bridge, at an interchange with I-29 in Sioux City, Iowa.