It is a discontinuous highway with two segments which combine for a length of 18 miles (29 km).

The west terminus of the eastern segment of Nebraska Highway 62 is at U.S. Highway 75 west of Stella, while its eastern terminus is at Nebraska Highway 67 east of Shubert.

It goes east through farmland, crosses the Big Nemaha River and meets S-49B, a spur road into Elk Creek.

It then continues east to Nebraska Highway 105 and ends in southwestern Nemaha County.

It continues east through farmland to Stella and then Shubert, and ends at Nebraska Highway 67.