[1] She then played the leading roles of Delia Banai on Girlfriends' Guide to Divorce and Special Agent Hannah Khoury on NCIS: New Orleans.
[2] From 2005 to 2009, Zadegan had roles in such television series as The Bernie Mac Show, Nip/Tuck, NCIS: Naval Criminal Investigative Service, The Unit, How I Met Your Mother, Big Shots, Lost, The Shield, and CSI: Miami.
In 2009, Zadegan appeared in the Persian language stage production of From Satellite with Love "Az Mahvareh Ta Eshgh", touring in the U.S. and Europe.
[8] That same year she also appeared opposite Michael Sheen and Samuel L. Jackson in the role of Jehan Younger in the Columbia TriStar psychological thriller Unthinkable.
[11] In 2015 Zadegan continued to appear in other television series such as Extant, Legends and as the Queen of Iran opposite Michael Sheen for Showtime's critical success Masters of Sex.