[1] The series is about a talented but self-absorbed surgeon (Patrick Wilson) who starts questioning his purpose in life when he is visited by the spirit of his deceased ex-wife (Jennifer Ehle).

His life is thrown into disarray, however, when he is visited by the ghost of his ex-wife Anna Paul (Jennifer Ehle), who was recently killed in a car accident.

While there, the friend runs away, but Michael encounters a former football player on whom he performed a surgery years earlier, but who has since become homeless and lost much of his memory.

Meanwhile, a teenage girl is brought to Holt Neuro, due to problems coping with the recent murder of her best friend, and it's suggested that she take the beta-blocker propranolol to treat the condition.

[24] David Hinckley of the New York Daily News gave the show three stars out of five, saying "The cast here nails their roles, from Wilson down to support players like Emmy winner Margo Martindale as his loyal assistant, Rita.

"[25] Mary McNamara of the Los Angeles Times said "with just a few tiny modifications, A Gifted Man could be a smart satiric comedy, but I don’t think that is what Grant is shooting for," poking fun at Julie Benz's character's cosmic beliefs and dysfunctional family.