[7] Ned Duane Heindel was born on September 4, 1937, in Red Lion, York County, Pennsylvania, to Mr. and Mrs. Penrose H.
After activation by ultraviolet light, lipophilic dipyranone (NDH2476) was found to inhibit abnormal Keratinocyte growth with an IC50 of 9 nanomolar concentration.
Gem di-methylation, double bond hydrogenation, or non-linear, angular geometry to the dipyranone greatly reduced or even eliminated the photo-cytotoxicity.
[25][10] Heindel's lab has developed an indomethacin prodrug, NDH4338, designed for use as a wound-healing accelerant for vesicant-triggered skin lesions.
The drug is a trifunctional pharmaceutical composed of covalently linked inhibitors of COX-2, acetylcholinesterase, and induced nitric oxide synthase which can be released in vivo from the parent molecule.
[19][26] Hydroxamate compounds developed by Heindel's lab have been found to enhance corneal wound healing after mustard exposure.
Among his publications he has examined "The Professionalization of American Chemistry: How the German Ph.D. Model Crossed the Atlantic",[36] and the careers of early photochemists such as Giacomo Ciamician.
Heindel and Robert D. Rapp translate and examine recipes in 19th century books of veterinary practice, or "Pferdartz", from the Moravian and the Pennsylvania Dutch traditions.
[38][39] In Hexenkopf, History, Healing and Hexerei, he examines traditions of both white and black magic in the Wilhelm and Saylor families of Northampton County, Pennsylvania.
Healers such as Johann Peter Seilor[40] and Emanuel Wilhelm used tonics, personalized prescriptions and manipulations to treat sickness and fight off evil in the tradition of white magic or "Braucherei".
[48] Over a 50 year period, Ned and Linda Heindel have purchased and preserved 128 acres of "forest, bogs and meadows" around the stone farmhouse in which they live, in Williams Township, Northampton County, Pennsylvania.
The hilly area includes stands of ash, poplar and oak trees, wild azalea, freshwater springs and Hexenkopf Rock, a ridge of exposed Precambrian stone.
[49] Linda Heindel serves as the secretary of the Land Preservation Board of Williams Township, Northampton County, PA.[50] As of August 2014, a consortium of energy companies announced plans to build the PennEast Pipeline to carry natural gas from the Marcellus Shale in Pennsylvania into New Jersey.