Krishnamurthy was born in 1927 at Kothapalli, Pithapuram Taluka, Godavari dt, Andhra Pradesh in what was then British India to Rama Murthy Panthulu and Vijayalakshmi.

[2] Krishnamurthy joined the Maharaja's Music College at Vizianagaram in the year 1940 and received initial training in Violin and Vocal from the Dwaram Narasinga Rao Naidu.

[2] Nedunuri's performances are characterised by adherence to tradition and his alapanas are renowned for capturing the essence of important Carnatic ragas.

He formed a popular partnership with the renowned violinist, Lalgudi Jayaraman, and the performances of the duo are much admired by listeners.

[3][2] Nedunuri Krishnamurthy died on 8 December 2014 at Visakhapatnam, aged 87, while undergoing treatment for lung cancer.