She sings mainly in Hindi films, but has also sung in Marathi, Telugu, Tamil, Kannada, Bengali, Punjabi and English.

She rose to prominence after recording "Ishq Wala Love" for Student of the Year (2012), ultimately winning the Filmfare R. D. Burman Award for New Music Talent and was nominated for the Best Female Playback Singer for "Jiya Re" from Jab Tak Hai Jaan (2012).

Her rendition of six jazz tracks in the soundtrack album of Amit Trivedi's Bombay Velvet (2015) received positive review from music critics.

[15] Mohan made her Bollywood debut with the Vishal–Shekhar-composed Student of the Year (2012), where she performed the soft-ballad "Ishq Wala Love", along with Salim Merchant and Shekhar Ravjiani.

[21] The following year, Mohan lent her voice for Ayushmann Khurrana's Punjabi track, "Saadi Galli Aaja", co-composed, co-written and co-sung by Khurana.

[23] Mohan performed the track "Kashmir Main Tu Kanyakumari" for the Vishal–Shekhar composed Chennai Express, along with Sunidhi Chauhan and Arijit Singh.

[25][26] While Mohan and Rashid Ali were performing in a Rahman's concert show, he came up with the idea to bring a duet between the two, since "both shares similar vocal texture".

[28][29] Moreover, Mohan along with Aditi Singh Sharma performed an electronic dance music styled "Pinacolada" from Darr @ The Mall, marketed as the first Gothic Bollywood song.

[31] Apart from rendering Sajid–Wajid's "Galat Baat Hai" from Main Tera Hero, for which Rajiv Vijayakar of Bollywood Hungama considered Mohan's vocals "spirited", she lent to voice for "Kambal Ke Neeche" from the Ismail Darbar-composed Kaanchi.

Aishwarya from Koimoi felt that Mohan's talent was "misused" in the songs "Catch Me If You Can" and "Dard Dilo Ke" from The Xposé.

[35] Similar sentiments were echoed for the songs "Caller Tune" and "Look Into My Eyes" from Humshakals, where Aishwarya stated, "Mohan did not show any variation that fans know she is capable of, as far as this album is concerned".

[39][40] Besides, Mohan provided backing vocals for the track "Makhna", featuring Sukhwinder Singh in the Rahman-composed American film Million Dollar Arm.

[43] Trivedi was in search of a voice with an "Asha Bhosle meets Nina Simone" tonal quality for Anushka Sharma's jazz singer character Rosie in the film, when he considered Mohan as the choice.

[6][44] According to The Indian Express, "what has worked" in the song "Mohabbat Buri Bimari" is Mohan's extemporisation in the middle of the track—with all the hiccups, laughs and squeals in place.

[46] Additionally, Mohan recorded a track titled "Naak Pe Gussa" for the film, which was inspired by K. M. Nanavati v. State of Maharashtra case.

[48] During the year, she teamed up with Ankit Tiwari for "Aalif Se" in Mr. X and worked with Shankar–Ehsaan–Loy for "Sarfira" in Katti Batti, where R. M. Vijayakar from India West stated that "Mohan stand out as the best thing in the film's soundtrack".

[52] Later the year, Mohan was roped in to perform the song "Neeyum Nannum" from Naanum Rowdy Dhaan which was composed and co-sung by Ravichander.

The last release of the year featured Mohan in an Amaal Mallik composition; a recreation of the song "Tumhe Apna Banane Ka" from Sadak (1991).

India West praised Mohan in their review of the music album; "Her resonant timber moves to soothing and back to haunting in an instant with enviable skill".

[70] Mohan collaborated with Pritam and Rochak Kohli for two albums; Jab Harry Met Sejal and Lucknow Central respectively, where she performed the song "Raula" with Diljit Dosanjh for the former.

[71][72] Additionally, she contributed to the music album of Baadshaho by performing a retro-contemporary fused item song "Piya More" with Mika Singh for an Ankit Tiwari-composition and also by recording the recreated version of "Keh Doon Tumhe" from Deewaar (1975).

In November 2020, she voiced the character of ‘Queen Poppy’ from Hindi dubbed version of popular animated musical comedy ‘Trolls World Tour’.

[79] She considered Mangeshkar as her "greatest teacher for playback",[5] while she credited A. R. Rahman for making her sustain her standard; "He is a task master but he gets the best out of you.

[21] Mohan credits the 1971 released song "Imagine" by John Lennon for inspiring on achieving her dreams with the "right kind of dedication".

[81] The same month, Mohan took part in the musical concert held in New Delhi for raising funds for the flood affected people of Assam.

[82] In June 2016, she performed at Smile Foundation's charity gala dinner, to support the cause of empowerment of underprivileged children and youth.

[83] In January 2017, she collaborated with United Nations on a project aimed at empowering women, ending human trafficking and promoting gender equality.