[1] She served in high offices in the government and the religious administration of Ancient Egypt.

It has been pointed out however, that if Neferure had become a great royal wife of Thutmose III, she would have been attested with that title, which is not known to be the case.

[3] The heir to the throne, Thutmose III, was only a child and Hatshepsut served as his regent, but by the seventh year of his rule it is well documented that Hatshepsut took on the role of pharaoh and continued to rule until her death, for more than twenty years.

[2][4] Neferure was tutored by some of Hatshepsut's most trusted advisers, at first Ahmose Pen-Nekhebet, who served under several of the preceding pharaohs and was held in great esteem.

After Hatshepsut became regent, Senenmut became her advisor and the role of tutor for Neferure was handed over to the administrator Senimen.

[4] These offices had to be filled by a royal woman in order to fulfill the religious and ceremonial duties, normally of the queen, in the government and the temples.

[5] Perhaps significantly, this royal title had been held by several queens of her dynasty including her mother, and this woman played an important role in temple rituals with the pharaoh.

Historian Kara Cooney has argued that in Neferure's assumption of the post of God's Wife of Amun and a dramatic increase in political authority thanks to Hatshepsut's kingship had upset the balance of patriarchal power in a drastic way.

[7] Neferure's presence has been all but obliterated from the material record, however one Egyptologist has attributed a large relief in the Mortuary Temple of Hatshepsut originally depicted Neferure but was later modified to depict Hatshepsut's mother Ahmes.

[1] It was noted that the tomb had been used, however, since the ceiling was smoothed and the walls plastered;[9] traces of ochre and yellow paints could be defined.