Negrilla de Palencia is a sparsely populated village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon.

It is located 17 kilometres (11 mi) from the provincial capital city of Salamanca and has a population of 97 people.

The municipality covers an area of 12 km2 (4.6 sq mi).

It lies 824 metres (2,703 ft) above sea level.

This article about a location in the province of Salamanca, Spain, is a stub.