Chamisa was the MDC Alliance's candidate for president in the 2018 general election, having previously been the leader of the party's youth assembly.

In Parliament, he was chair of the portfolio committees of Defence and Home Affairs, Public Accounts, Gender and Youth, and Transport and Communications.

In March 2007 he was attacked at Harare International Airport as he attempted to leave the country for Belgium; he was admitted to a hospital with a broken skull.

"[6] On 10 February 2009, Morgan Tsvangirai designated Chamisa for the position of Minister of Information, Communication, and Technology as part of the national unity government.

The Herald reported on 10 April 2009, that President Robert Mugabe had assigned responsibility for telecommunications to the Ministry of Transport, headed by Nicholas Goche.

[8] Chamisa and Tsvangirai objected to this decision, saying that Mugabe had no power to unilaterally assign telecommunications to another ministry under the terms of the power-sharing agreement.

Chamisa has been accused of barring other youth and student leaders from having closer access to party president Tsvangirai, a move allegedly meant to protect his position.

On 14 February 2018, it was announced that Tsvangirai had succumbed to colon cancer in the hospital and the next day, the Party's national council appointed Chamisa acting president for a period of 12 months effectively elbowing Mudzuri and Khupe out.

After the failure to convince the Constitutional Court, Chamisa questioned the independence of the judiciary and has since promised his supporters a strategy to regain stolen electoral victory.

"[21] Morgan Tsvangirai (Prime Minister) Arthur Mutambara / Thokozani Khuphe (Deputy Prime Ministers) Tendai Biti (Finance) Elphas Mukonoweshuro ( Public Service) Henry Dzinotyiwei (Science and Technology Development) Elton Mangoma (Economic Planning and Investment Promotion) Priscilla Misihairabwi-Mushonga (Regional Integration and International Cooperation) Giles Mutsekwa / Kembo Mohadi (Home Affairs) Henry Madzorera (Health and Child Welfare) David Coltart (Education, Sport and Culture) Eric Matinenga (Constitutional and Parliamentary Affairs) Olivia Muchena (Women Affairs, Gender and Community Development Emmerson Mnangagwa (Defence) Saviour Kasukuwere (Youth Development, Indigenisation and Empowerment) Ignatius Chombo (Local Government and Urban Development) Patrick Chinamasa (Justice ) Joseph Made (Agriculture) Herbert Murerwa (Lands and Land Resettlement) Francis Nhema (Environment) Walter Mzembi (Tourism) Nicholas Goche (Transport) Obert Mpofu (Mines and Mining Development) Samuel Sipepa Nkomo (State Enterprise and Parastatals) Nelson Chamisa (Information and Communications Technology) Welshman Ncube (Industry and Commerce) Theresa Makoni (Public Works) Fidelis Mhashu (National Housing and Social Amenities) Elias Mudzuri (Energy and Power Development) Joel Gabuza (Water Resources and Development Paurine Mpariwa (Labour and Social Welfare Simbarashe Mumbengegwi (Foreign Affairs) Webster Shamu (Information and Publicity) Stan Mudenge (Higher and Tertiary Education)