[2] In 2020 she was removed from the position of party president by Douglas Mwonzora amid strong claims of violence and cheating from her fans.

[5] In 1999 she participated in the formation of the Movement for Democratic Change party, in which she was elected as a National Executive member responsible for Transport, Logistics and Welfare.

[9] Khupe was Deputy Prime Minister of Zimbabwe from 11 February 2009 to August 2013 in the government of national unity between the MDC-T and ZANU-PF.

[11] In 2005 she was elected vice-president of the Movement for Democratic Change (MDC)[12][13] taking over from veteran trade unionist Gibson Sibanda.

[16] Morgan Tsvangirai (Prime Minister) Arthur Mutambara / Thokozani Khuphe (Deputy Prime Ministers) Tendai Biti (Finance) Elphas Mukonoweshuro ( Public Service) Henry Dzinotyiwei (Science and Technology Development) Elton Mangoma (Economic Planning and Investment Promotion) Priscilla Misihairabwi-Mushonga (Regional Integration and International Cooperation) Giles Mutsekwa / Kembo Mohadi (Home Affairs) Henry Madzorera (Health and Child Welfare) David Coltart (Education, Sport and Culture) Eric Matinenga (Constitutional and Parliamentary Affairs) Olivia Muchena (Women Affairs, Gender and Community Development Emmerson Mnangagwa (Defence) Saviour Kasukuwere (Youth Development, Indigenisation and Empowerment) Ignatius Chombo (Local Government and Urban Development) Patrick Chinamasa (Justice ) Joseph Made (Agriculture) Herbert Murerwa (Lands and Land Resettlement) Francis Nhema (Environment) Walter Mzembi (Tourism) Nicholas Goche (Transport) Obert Mpofu (Mines and Mining Development) Samuel Sipepa Nkomo (State Enterprise and Parastatals) Nelson Chamisa (Information and Communications Technology) Welshman Ncube (Industry and Commerce) Theresa Makoni (Public Works) Fidelis Mhashu (National Housing and Social Amenities) Elias Mudzuri (Energy and Power Development) Joel Gabuza (Water Resources and Development Paurine Mpariwa (Labour and Social Welfare Simbarashe Mumbengegwi (Foreign Affairs) Webster Shamu (Information and Publicity) Stan Mudenge (Higher and Tertiary Education)