After the completion of the construction of the Railway station in 1884, it became one of the city's main infrastructure links, a "location where traffic arteries of the capital intersect".

[5] One of the first permanent cinemas in Belgrade, in the kafana "Crna Mačka" (Black Cat), was opened in the Nemanjina Street after 1909.

[6] During the major, catastrophic hailstorm which engulfed the entire Belgrade on 11 September 1967, the torrent formed down the street, recreating the former stream.

Even the waves formed on the street, which were turning cars upside down and breaking off the entire blocks of cobblestone.

The closing of the Nemanjina caused a major disturbance in the traffic, especially in the routes of the public transportation lines.

The Government Building in front of which Serbian prime minister Zoran Đinđić was assassinated 12 March 2003 is also located in this street.

Built during the rule of Alexander Obrenović, it was considered one of the most beautiful buildings in Belgrade at the time and hosted the elite guard's unit.

However, it was the guards unit from this very barrack who conducted the May Coup in 1903 when the Obrenović dynasty was dethroned and King Alexander and Queen Draga were executed.

[9] The building was located in the Military Quarter of Belgrade, which extended between the streets of Kneza Miloša, Kralja Milana, Birčaninova and the Slavija Square.

Rows of simple, three-light windows, shallow decoration and a certain asymmetry between the entrance and avant-corps, shows elements of early Belgrade Modernism.

Due to its use, first by the working class, later as an educational and cultural venue, the building also holds a non-material heritage importance.

Project was changed to include draining of the terrain, deep foundations of reinforced concrete and, construction-wise, division into 8 independent blocks.

Façade is ornamented with stone sculptures, authored by Toma Rosandić, Lojze Dolinar, Dragomir Arambašić, Živojin Lukić and Risto Stijović.

It was declared a cultural monument in 2007, as part of the protected complex "Area along the Kneza Miloša Street".

Brkić designed colored and ornamented façade, a major change in post-World War II architecture, mostly dominated by the Socialist realism imported by the post-war Communist government.

[12] In December 2015, prime minister Aleksandar Vučić encouraged the local authorities to build a monument to Stefan Nemanja at Manjež park, which is located at the central part of the street.

[14] In April 2017 it was announced that the monument would be located 100 m (330 ft) down the street, in the clearing in front of the demolished Yugoslav Ministry of Defense building.

In September 2017, the city administration decided that the monument would be located at the lower ending section of the street, on the square of Savski Trg across the Main railway station which is envisioned as the future Museum of Medieval Serbia.