It flows north 11.2 miles (18.0 km)[1][2] from Assawompset Pond in Lakeville and through Middleborough where it empties into the Taunton River.
The Native American Wampanoag Indians would leave their winter encampments inland and navigate the Taunton River to the Nemasket River in the early spring to take advantage of the alewife run and relocate to their summer encampment on Betty's Neck on Assawompsett Pond.
When Oliver Mills built the factory that spanned the river, it created contention with the Wampanoags by forcing them to portage around the facility.
During the late 19th century, several steamboats were operated along the Nemasket, offering cruises of the river and into Assawompsett Pond.
[9] Other common wildlife in the area include deer, foxes, coyotes, river otters, raccoons, skunks, and opossums.