Nenagh is in the Barony of Ormond Lower, which was the traditional territory of the O'Kennedys before the Norman invasion of Ireland.

[6] The town was one of the ancient manors of the Butlers, who received the grant of a fair from Henry VIII of England.

A small settlement grew up around the castle, but it never seems to have been of any great importance other than as a local market throughout the medieval period.

In the rebellion of 1641 Nenagh Castle was garrisoned by George Hamilton for James Butler, the twelfth Earl of Ormonde (later the first Duke).

It was taken by Phelim O'Neill in 1648 during Owen Roe's journey south via the silver mines but was re-taken by Murrough O'Brien, 1st Earl of Inchiquin in the same year and George Hamilton was back again as governor to face Major-General Henry Ireton and Colonel Daniel Abbott in 1650.

After the Restoration, Sir William Flower came along in 1660 on behalf of the Marchioness of Ormond, who had the ownership of the Manor on her marriage settlements.

[6] In this period Daniel O'Connell held one of his Monster meetings for Repeal of the Act of Union at Grange outside of Nenagh.

In the 19th century, Nenagh was primarily a market town, providing services to the agricultural hinterland.

Industries included brewing, corn processing, coach building and iron works with the addition of cottage industries such as tailoring, dressmaking, millinery, shoemaking, carpentry, wood-turning, wheelwrighting, harnessmaking, printing, and monumental sculpting.

[12] The Nenagh Co-operative Creamery was established in 1914 providing employment in milk processing and butter-making.

[13] The town's historic features include Nenagh Castle, the Heritage Centre and the ruined Franciscan abbey.

[11] The crown of crenellations and ring of clerestory windows were added at the instigation of Bishop Michael Flannery in 1861.

[11] The keep now features on the logos of a number of local clubs and businesses including Nenagh Town Council.

The Governor's Residence and jail gatehouse house Nenagh & District Heritage Centre.

[6] In 2002, the grounds of the refurbished courthouse became the site of bronze sculptures of Matt McGrath, Bob Tisdall and Johnny Hayes, three Olympic gold medalists with Nenagh links.

The building was designed by the then Town Engineer Robert Gill (father of Tomás Mac Giolla).

Built in the International Style of mostly flat roof and rendered walls the hospital was retro-fitted with uPVC windows at a later date.

The M7 by-passes the town to the south and provides high quality access to the cities of Limerick and Dublin.

Nenagh railway station is also served infrequently by a small number of journeys on Bus Éireann route 323.

Passengers can connect at Ballybrophy to trains heading northeast to Dublin or southwest to Cork or Tralee.

[31] A committee (the Nenagh Rail Steering Committee) working in conjunction with Irish Railway News, had a meeting with the national railway company Iarnród Éireann (IÉ) on 1 September 2005 to present the results of a traffic study funded by Nenagh Town Council and North Tipperary County Council, and to seek a morning and evening service between Nenagh and Limerick which would increase commuter traffic.

[32] Nenagh is only 37 km from Thurles, which is on the main Dublin/Cork line, and which has around 18 trains daily in each direction, including non-stop services to and from Dublin.

The All-Ireland League club has produced three full Irish International players: Tony Courtney in the 1920s and more recently Trevor Hogan, Cronan Gleeson and Donnacha Ryan.

[36] The club also possesses Ireland's first and to date only international standard indoor athletics track at Tyone.