The players take the roles of these beings as they adapt to their newly symbiotic existence and learn the secrets hidden behind veils of obscurity and mysticism, seeking the path toward enlightenment, Agartha.

It also introduces Ar-Kaïm and intuitive magic in the style of Mage: The Ascension (although based on elements and words instead of spheres).

The Knights Templar is one of the primary sources of antagonists for Nephilim, who along with the Rosicrucians supply the most organized opposition.

The Order of the Black Star possess many magical secrets, but are fewer in numbers and less likely to team up against Nephilim.

The English language edition of Nephilim uses the Basic Role-Playing system used in many other Chaosium products, such as Call of Cthulhu, Pendragon and RuneQuest.

Some of the books published for Nephilim's Third Edition (by MultiSim in French) include: Some of the books published for Nephilim's Fifth Edition (by Mnémos in French) include: A second crowdfunding finished on 25/06/2020 and with this some new books will be published in April 2021 In Issue 13 of Arcane, Andy Butcher noted that Nephilim gamemasters have to work very hard to prepare the game for play since the original rulebook did not contain a lot of information about running adventures.