The town is known for its mineral springs, sold and bottled under the Acqua di Nepi brand throughout Italy.

Nepet became Roman before 386 BC, when Livy speaks of it and Sutrium as the keys of Etruria.

It was among the twelve Latin colonies that refused further help to Rome in 209 BC.

It is hardly mentioned in Imperial times,[4] except as a station on the road (Via Amerina) which diverged from the Via Cassia near the modern Settevene and ran to Amelia and Todi.

[4] During the late 9th to early 10th century, it was, along with much of central Italy, threatened by the Saracens.