In 1957, his family repatriated to Soviet Armenia, and he continued his studies there at the Gevorkian Theological Seminary of the Mother See of Holy Etchmiadzin.

In 1977, Pozapalian was awarded a special Letter of Gratitude by the English Queen Elizabeth II.

At the request of Vasken I, he returned to the Mother See of Holy Etchmiadzin in 1982 and was appointed to serve as the Chancellor of the Catholicosate of All Armenians.

In 2000, on the 40th anniversary of his ordination to the priesthood, Pozapalian sponsored the construction of the Holy Martyrs Church in the village of Teghenik, in memory of his parents.

On this occasion he was awarded the order of St. Gregory the Illuminator by the Catholicos of All Armenians Karekin II.

Archbishop Nerses was seriously injured in a robbery attack in his home at the Mother See on February 18, 2009, and was hospitalized in a coma.