However, during parts of the year, Nescopeck Creek is impossible to navigate due to rapids, flooding, and tight bends.

Eventually, the creek passes the northwestern edge of Mount Yeager and continues into Butler Township.

It continues west in this township, receiving the tributary Little Nescopeck Creek B, crossing Pennsylvania Route 93, and making several meanders.

One hundred thirteen very small streams in the Nescopeck Creek watershed have a Strahler number of 1.

However, the largest source of pollution in the Nescopeck Creek watershed is acid mine drainage (AMD).

[22] However, the eastern reaches of the Nescopeck Creek watershed are near the border of the Appalachian Plateau region.

[26] Another twenty-four percent of the Nescopeck Creek watershed is made up of the Leck Kill-Meckesville-Calvin series.

[26] Eleven percent of Nescopeck Creek's watershed is made up of the Udorthents-Urban Land-Volusia series.

Nescopeck Creek's watershed area includes one city, five boroughs, and thirteen townships.

Thirteen percent of the land in the Nescopeck Creek watershed is owned by the state of Pennsylvania.

[29] Four to seven percent of the Nescopeck Creek watershed consists of mines, quarries, and gravel pits.

A number of streams in the upper Nescopeck Creek watershed, in fact, have more than 80 percent forest coverage.

The area close to the main stem of the creek upstream to several miles from the source is in the range of 997 to 1,161 feet (304 to 354 m).

In the central part of the Nescopeck Creek watershed, several tributaries also lie in this elevation range.

[37] Nescopeck Creek's name comes from a Lenape word meaning "deep black waters".

The Lenni Lenape inhabited the Nescopeck Creek watershed a thousand years before European settlers.

By the 1700s, the Lenni Lenape had left the Nescopeck Creek watershed due to encroaching Iroquois and European settlers.

[40] In the early 1700s, some European settlers, who were granted warrants by William Penn, explored Native American trails in the Nescopeck Creek watershed.

One example is the Sugarloaf Massacre, when a group of Native Americans ambushed some soldiers on the Lehigh Path near Nescopeck Creek in 1780.

[41] Light industries, such as lumbering and tanning, gradually developed in the Nescopeck Creek watershed.

This led to the creation of numerous communities in the Nescopeck Creek watershed, such as White Haven, Freeland, and Hazleton.

In the 1830s and 1840s, a number of "patch towns" designed to attend mines were built in the Nescopeck Creek watershed.

[43] In 1885, a number of French Indian artifacts, which were Plaster of Paris casts for making sculptures, were discovered along Nescopeck Creek in Dennison Township.

[48] After World War II, there was a large increase in unemployment rates in the Nescopeck Creek watershed due to the failing coal mining industry.

The lowest density of snake species in the watershed is along the central part of Nescopeck Creek.

[59] The Edgewood vernal pools provide a breeding ground for wood frogs and Jefferson salamanders.

[57] The Bird Community Index, a measure of the quality of a habitat based on the presence of songbirds, has been tested for most of the watershed of Nescopeck Creek.

[60] The Hilsenhoff Biotic Index (HBI) has been measured for a number of sites along Nescopeck Creek and its tributaries.

Bracken fern, teaberry, black chokeberry, blueberry, and huckleberry are the most common shrubs in this habitat.

Since the late 1990s, there have been plans to convert old railroad lines in the Nescopeck Creek watershed to rail trails.