Nesle (French pronunciation: [nɛl]) is a commune in the Somme department in Hauts-de-France in northern France.

Nesle is situated at the junction of the D930 and D337 roads, some 16 miles (26 km) southwest of Saint-Quentin.

Simon II of Clermont, Seigneur of Nesle through his mother Gertrude, was regent of the kingdom of France during the second crusade of Saint Louis.

The brothers Raoul and Guy I were both notable casualties of the Battle of the Golden Spurs 1302, a French military disaster in the County of Flanders in the Franco-Flemish War (1297–1305).

His grandson, Louis de Mailly, had five daughters, of whom four (the Countess of Mailly, the Duchess of Lauragais, the Countess of Vintimille, and the Marquise de la Tournelle, afterwards the Duchess of Châteauroux) were successively, or simultaneously, mistresses of Louis XV.