Nespelem is a town in Okanogan County, Washington, United States.

The name Nespelem is derived from a local Native American term meaning "large flat meadow".

[4] Nespelem was founded by the Yakama leader Chief Kamiakin and officially incorporated on April 15, 1935.

It is the site of a historic Nez Perce cemetery, which was the original burial ground of Chief Joseph.

[5] According to the United States Census Bureau, the town has a total area of 0.19 square miles (0.49 km2), all of it land.

17.3% of all households were made up of individuals, and 6.7% had someone living alone who was 65 years of age or older.

About 15.9% of families and 16.9% of the population were below the poverty line, including 28.3% of those under the age of eighteen and 4.8% of those 65 or over.